Low-Substituted Hydroxypropyl  Cellulose, NF,  EP*, JP

L-HPC (Low-Substituted Hydroxypropyl Cellulose) was first approved in 1977 as a disintegrant for pharmaceutical dosage forms in Japan. In addition to the conventional LH grades, NBD grades which have improved flowability and compressibility were newly introduced in 2011. A recent survey shows that L-HPC is ranked as the first choice of tablet disintegrant by Japanese pharmaceutical companies.

The key benefits of L-HPC include:

• Higher stability due to its non-ionic nature and low hygroscopicity

• Disintegration into smaller particles leading to better

 dissolution

• Anti-capping effect for tableting process
• Suitable for pellet extrusion as well as tableting
• A variety of grades are available depending on application

Features:

• Water insoluble, swells in water and work as dual functional ingredients, disintegrant and  binder for tablets and  pellets.
• Suitable grade can be selected  depending on process and API characteristics.
• Non-ionic polymer,  has less interaction with API and  better stability.