ECG 505 , NS-300

Carboxymethylcellulose Calcium (ECG-505) and Carmellose Calcium (NS-300) have been produced under strict quality control, and have been widely used as agents for disintegration and dispersion of tablets and granules.

ECG-505 and NS-300 rapidly absorb the water needed for swelling and consequently show a very short disintegration time.

The process of dispersion to powder caused by the disintegration of tablets and granules is very important for promoting the solubility and thereby the bioavailability of drugs.

ECG-505 is insoluble but shows hydrophilic property in water due to its chemlate structure and calcium component. NS-300 of carboxylic acid type shows poor hydration but shows a sufficient disintegration function by its electrostatic repulsive force.

PROPERTIES

ECG-505

NS-300

Degree of Substitution

0.5-0.7/C6

0.4-0.6/C6

Particle Through 300mesh

more than 95%

more than 95%

Bulk Density

500-600gle

300-400gle

Solubility: Distilled Water
0.1N NaOH

Insoluble
Swellable
Gelation

Insoluble
Swellable
Gelation

pH

4.5-6.0

3.5-5.0

Stability: Sunlight

Stable

Stable

 

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