L-HPC

Low-Substituted Hydroxypropyl  Cellulose, NF,  EP*, JP

 

 

L-HPC (Low-Substituted Hydroxypropyl Cellulose) was first approved in 1977 as a disintegrant for pharmaceutical dosage forms in Japan. In addition to the conventional LH grades, NBD grades which have improved flowability and compressibility were newly introduced in 2011. A recent survey shows that L-HPC is ranked as the first choice of tablet disintegrant by Japanese pharmaceutical companies.

The key benefits of L-HPC include:

  • Higher stability due to its non-ionic nature and low hygroscopicity
  • Disintegration into smaller particles leading to better

 dissolution

  • Anti-capping effect for tableting process
  • Suitable for pellet extrusion as well as tableting
  • A variety of grades are available depending on application

Features:

  • Water insoluble, swells in water and work as dual functional ingredients, disintegrant and  binder for tablets and  pellets.
  • Suitable grade can be selected  depending on process and API characteristics.
  • Non-ionic polymer,  has less interaction with API and  better stability.

                        

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