Low-Substituted Hydroxypropyl  Cellulose, NF,  EP*, JP



L-HPC (Low-Substituted Hydroxypropyl Cellulose) was first approved in 1977 as a disintegrant for pharmaceutical dosage forms in Japan. In addition to the conventional LH grades, NBD grades which have improved flowability and compressibility were newly introduced in 2011. A recent survey shows that L-HPC is ranked as the first choice of tablet disintegrant by Japanese pharmaceutical companies.

The key benefits of L-HPC include:

  • Higher stability due to its non-ionic nature and low hygroscopicity
  • Disintegration into smaller particles leading to better


  • Anti-capping effect for tableting process
  • Suitable for pellet extrusion as well as tableting
  • A variety of grades are available depending on application


  • Water insoluble, swells in water and work as dual functional ingredients, disintegrant and  binder for tablets and  pellets.
  • Suitable grade can be selected  depending on process and API characteristics.
  • Non-ionic polymer,  has less interaction with API and  better stability.


JL H Ten Raya No 41A, RT.4/RW.1, Rawamangun Kayu Putih Pulo Gadung Jakarta Timur DKI Jakarta 13210
Phone: 6221-4752920
Fax: 6221-4892659
Email: cs@lawsim.com